SCHEMBL25997484

SCHEMBL25997484

Cc1ccc(COc2ccc(/C=C3\SC(=S)N(CC(=O)O)C3=O)cc2)cc1

nearest known ligand 0.83

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 9/20 0.83
PTPN1 P18031 7/20 0.83
MMP3 P08254 3/20 0.83
MMP13 P45452 3/20 0.83
GFER P55789 1/20 0.66
MEN1 O00255 2/20 0.65
POLB P06746 2/20 0.65
KMT2A Q03164 2/20 0.65
ADAMTS5 Q9UNA0 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6886677 0.92 AKR1B1 (0.83) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL6886682 0.92 AKR1B1 (0.83) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL19736228 0.91 AKR1B1 (1.00) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL17319262 0.91 AKR1B1 (1.00) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL1060503 0.91 AKR1B1 (1.00) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL12008504 0.90 MAPT (0.74) AKR1B1PTPN1MMP3MMP13MEN1
SCHEMBL29408634 0.90 AKR1B1 (0.83) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL19736097 0.90 AKR1B1 (0.83) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL12008520 0.88 MAPT (0.66) AKR1B1PTPN1MMP3MMP13MEN1
SCHEMBL25992272 0.88 AKR1B1 (0.85) AKR1B1PTPN1MMP3MMP13GFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3468555-B1 COMPOSITIONS FOR USE IN TREATING BACTERIAL INFECTIONS VERSITECH LTD (HK) 2023-08-09 EP disclosed