SCHEMBL1060503

SCHEMBL1060503

O=C(O)CN1C(=O)C(=Cc2ccc(OCc3ccccc3)cc2)SC1=S

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 10/20 1.00
PTPN1 P18031 8/20 1.00
MMP3 P08254 3/20 1.00
MMP13 P45452 3/20 1.00
GFER P55789 1/20 0.79
ADAMTS5 Q9UNA0 1/20 0.76
MEN1 O00255 2/20 0.70
KMT2A Q03164 2/20 0.70
PSMD14 O00487 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19736228 1.00 AKR1B1 (1.00) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL17319262 1.00 AKR1B1 (1.00) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL6886682 0.91 AKR1B1 (0.83) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL25997484 0.91 AKR1B1 (0.83) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL19736097 0.91 AKR1B1 (0.83) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL29408634 0.91 AKR1B1 (0.83) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL6886677 0.91 AKR1B1 (0.83) AKR1B1PTPN1MMP3MMP13GFER
SCHEMBL6879197 0.89 AKR1B1 (0.81) AKR1B1PTPN1MMP3MMP13ADAMTS5
SCHEMBL6879199 0.89 AKR1B1 (0.81) AKR1B1PTPN1MMP3MMP13ADAMTS5
SCHEMBL20534415 0.89 AKR1B1 (1.00) AKR1B1PTPN1MMP3MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2210940-B2 METHOD FOR HIGH-LEVEL SECRETION AND PRODUCTION OF PROTEIN DAIICHI SANKYO CO LTD (JP) 2018-07-18 EP claimed
EP-2022855-B1 HIGH SECRETION PRODUCTION METHOD OF PROTEIN DAIICHI SANKYO CO LTD (JP) 2015-08-19 EP claimed
EP-2210940-B1 METHOD FOR HIGH-LEVEL SECRETION AND PRODUCTION OF PROTEIN DAIICHI SANKYO CO LTD (JP) 2015-03-11 EP claimed
US-8409825-B2 Method for high-level secretory production of protein NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2013-04-02 US claimed
US-8232377-B2 Method for high-level secretory production of protein NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2012-07-31 US claimed
US-20110014651-A1 METHOD FOR HIGH-LEVEL SECRETORY PRODUCTION OF PROTEIN KYOWA HAKKO KIRIN CO., LTD. (JP) 2011-01-20 US claimed
EP-2210940-A1 METHOD FOR HIGH-LEVEL SECRETION AND PRODUCTION OF PROTEIN Daiichi Sankyo Company, Limited (JP) 2010-07-28 EP claimed
US-20090191587-A1 METHOD FOR HIGH-LEVEL SECRETORY PRODUCTION OF PROTEIN NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGKY 2009-07-30 US claimed
EP-2022855-A1 HIGH SECRETION PRODUCTION METHOD OF PROTEIN Kirin Pharma Kabushiki Kaisha (JP) 2009-02-11 EP claimed
US-20220378751-A1 INHIBITING DIHYDROFOLATE REDUCTASE IN A MICROORGANISM VERSITECH LIMITED (HK) 2022-12-01 US disclosed
CN-109414432-B Antimicrobial compounds and methods of use thereof 港大科桥有限公司 2022-03-08 CN disclosed
EP-3196304-B1 METHOD FOR IMPROVED HIGH-LEVEL SECRETORY PRODUCTION OF PROTEINS DAIICHI SANKYO CO LTD (JP) 2021-10-06 EP disclosed
EP-2210940-B2 METHOD FOR HIGH-LEVEL SECRETION AND PRODUCTION OF PROTEIN DAIICHI SANKYO CO LTD (JP) 2018-07-18 EP disclosed
US-20170211063-A1 METHOD FOR IMPROVED HIGH-LEVEL SECRETORY PRODUCTION OF PROTEIN DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-07-27 US disclosed
US-8409825-B2 Method for high-level secretory production of protein NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2013-04-02 US disclosed
US-8232377-B2 Method for high-level secretory production of protein NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2012-07-31 US disclosed
US-20110014651-A1 METHOD FOR HIGH-LEVEL SECRETORY PRODUCTION OF PROTEIN KYOWA HAKKO KIRIN CO., LTD. (JP) 2011-01-20 US disclosed
EP-2210940-A1 METHOD FOR HIGH-LEVEL SECRETION AND PRODUCTION OF PROTEIN Daiichi Sankyo Company, Limited (JP) 2010-07-28 EP disclosed
US-20090191587-A1 METHOD FOR HIGH-LEVEL SECRETORY PRODUCTION OF PROTEIN NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGKY 2009-07-30 US disclosed
EP-2022855-A1 HIGH SECRETION PRODUCTION METHOD OF PROTEIN Kirin Pharma Kabushiki Kaisha (JP) 2009-02-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220378751-A1 INHIBITING DIHYDROFOLATE REDUCTASE IN A MICROORGANISM DHFR, BLVRB, QDPR AKR1B1 92/4885PTPN1 1854/4885MMP3 1947/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.