Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.32 |
| ▸ | CLK1 | P49759 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22300408 | 0.75 | CYP1A2 (0.50) | POLBGRM2TGFBR1KDM4EGLA | |
| SCHEMBL23108642 | 0.74 | MET (0.42) | POLBCLK1KDM4E | |
| SCHEMBL21863408 | 0.73 | POLB (0.69) | POLBGRM2KDM4EGAA | |
| SCHEMBL23133610 | 0.72 | GRM2 (0.34) | GRM2KDM4EGLAGAA | |
| SCHEMBL24712162 | 0.71 | POLB (0.42) | POLBGRM2TGFBR1EIF2AK4KDM4E | |
| SCHEMBL17812869 | 0.71 | POLB (0.64) | POLBTGFBR1 | |
| SCHEMBL20600632 | 0.70 | POLB (0.41) | POLBGRM2TGFBR1KDM4EGLA | |
| SCHEMBL21729418 | 0.70 | POLB (0.38) | POLBGRM2TGFBR1EIF2AK4CLK1 | |
| SCHEMBL2259799 | 0.68 | POLB (0.37) | POLBTGFBR1CLK1TGFBR2 | |
| SCHEMBL18416824 | 0.67 | POLB (0.55) | POLBGRM2TGFBR1CLK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150601-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-08-10 | — | — | WO | disclosed |