Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | EBP | Q15125 | 1/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25358228 | 1.00 | SIGMAR1 (0.54) | SIGMAR1MEN1KMT2ADRD4DRD2 | |
| SCHEMBL26004216 | 0.91 | MEN1 (0.48) | SIGMAR1MEN1KMT2ADRD4DRD2 | |
| SCHEMBL25362300 | 0.90 | MEN1 (0.47) | SIGMAR1MEN1KMT2ADRD4DRD2 | |
| SCHEMBL26004166 | 0.90 | DRD4 (0.48) | SIGMAR1MEN1KMT2ADRD4DRD2 | |
| SCHEMBL25359715 | 0.90 | DRD4 (0.48) | SIGMAR1MEN1KMT2ADRD4DRD2 | |
| SCHEMBL26004276 | 0.90 | MEN1 (0.47) | SIGMAR1MEN1KMT2ADRD4DRD2 | |
| SCHEMBL25357242 | 0.89 | MEN1 (0.46) | SIGMAR1MEN1KMT2ADRD4DRD2 | |
| SCHEMBL30623484 | 0.89 | MEN1 (0.44) | SIGMAR1MEN1KMT2ADRD4DRD2 | |
| SCHEMBL25360846 | 0.89 | MEN1 (0.44) | SIGMAR1MEN1KMT2ADRD4DRD2 | |
| SCHEMBL26013065 | 0.89 | MEN1 (0.44) | SIGMAR1MEN1KMT2ADRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |