Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26004734 | 0.84 | SIGMAR1 (0.46) | SIGMAR1PRCP | |
| SCHEMBL26015090 | 0.84 | SIGMAR1 (0.44) | SIGMAR1PRCPOPRD1 | |
| SCHEMBL26004358 | 0.84 | SIGMAR1 (0.44) | SIGMAR1PRCP | |
| SCHEMBL26004359 | 0.83 | SIGMAR1 (0.44) | SIGMAR1PRCPGAAALOX12SMN1; SMN2 | |
| SCHEMBL26004354 | 0.83 | SIGMAR1 (0.49) | SIGMAR1PRCP | |
| SCHEMBL26015271 | 0.83 | SIGMAR1 (0.45) | SIGMAR1PRCP | |
| SCHEMBL26004355 | 0.82 | SIGMAR1 (0.44) | SIGMAR1PRCPOPRD1 | |
| SCHEMBL26004598 | 0.82 | SIGMAR1 (0.44) | SIGMAR1PRCP | |
| SCHEMBL26014965 | 0.82 | SIGMAR1 (0.41) | SIGMAR1PRCPOPRD1 | |
| SCHEMBL26004551 | 0.81 | SIGMAR1 (0.44) | SIGMAR1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |