Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.57 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 7/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2600570 | 0.91 | ABL1 (0.67) | ABL1MAP4K1IGF1RJAK2JAK3 | |
| SCHEMBL2600548 | 0.90 | ABL1 (0.48) | ABL1MAP4K1IGF1RLRRK2CYP3A4 | |
| SCHEMBL2600528 | 0.87 | ABL1 (0.60) | ABL1MAP4K1IGF1RJAK2JAK3 | |
| SCHEMBL2112267 | 0.87 | ABL1 (0.60) | ABL1MAP4K1IGF1RJAK2JAK3 | |
| SCHEMBL2112147 | 0.86 | ABL1 (0.59) | ABL1MAP4K1IGF1RJAK2JAK3 | |
| SCHEMBL2600541 | 0.86 | ABL1 (0.59) | ABL1MAP4K1IGF1RJAK2JAK3 | |
| SCHEMBL2600576 | 0.85 | MAP4K1 (0.58) | ABL1MAP4K1JAK2JAK3LRRK2 | |
| SCHEMBL2600524 | 0.84 | ABL1 (0.58) | ABL1MAP4K1IGF1RJAK2JAK3 | |
| SCHEMBL2600527 | 0.84 | ABL1 (0.57) | ABL1MAP4K1IGF1RJAK2JAK3 | |
| SCHEMBL2600554 | 0.81 | ABL1 (0.54) | ABL1MAP4K1LRRK2CYP3A4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158647-B2 | Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-20090005356-A1 | SUBSTITUTED PYRROLOPYRIDINES AND PYRAZOLOPYRIDINES AS KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005356-A1 | SUBSTITUTED PYRROLOPYRIDINES AND PYRAZOLOPYRIDINES AS KINASE MODULATORS | PDXK, MAP3K4, PDPK1 | ABL1 862/4885MAP4K1 16/4885IGF1R 1011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.