Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 2/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26009808 | 0.87 | ATR (0.40) | MAPKAPK5 | |
| SCHEMBL3042183 | 0.83 | AURKA (0.50) | AURKAAURKBEGFRNTRK1 | |
| SCHEMBL3044547 | 0.77 | SYK (0.33) | AURKAAURKB | |
| SCHEMBL26011193 | 0.74 | SYK (0.42) | AURKAAURKB | |
| SCHEMBL26007684 | 0.74 | PDE2A (0.33) | AURKAAURKB | |
| SCHEMBL26035235 | 0.74 | SYK (0.32) | AURKAAURKB | |
| SCHEMBL3031923 | 0.72 | IGF1R (0.45) | AURKAAURKBEGFRNTRK1 | |
| SCHEMBL13220902 | 0.72 | IGF1R (0.45) | AURKAAURKBEGFRNTRK1 | |
| SCHEMBL26007557 | 0.71 | SYK (0.40) | AURKAAURKB | |
| SCHEMBL26029263 | 0.71 | SYK (0.42) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154426-A1 | CDK INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |