Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25359123 | 0.85 | SIGMAR1 (0.56) | SIGMAR1ADRA2APRCPOPRM1OPRD1 | |
| SCHEMBL30623414 | 0.85 | SIGMAR1 (0.56) | SIGMAR1ADRA2APRCPOPRM1OPRD1 | |
| SCHEMBL26004429 | 0.84 | SIGMAR1 (0.46) | SIGMAR1PRCPOPRM1OPRD1OPRK1 | |
| SCHEMBL25361889 | 0.84 | SIGMAR1 (0.46) | SIGMAR1PRCPOPRM1OPRD1OPRK1 | |
| SCHEMBL26014001 | 0.84 | SIGMAR1 (0.46) | SIGMAR1PRCPOPRM1OPRD1OPRK1 | |
| SCHEMBL26012437 | 0.78 | DRD4 (0.55) | KCNH2 | |
| SCHEMBL26012148 | 0.78 | DRD4 (0.55) | KCNH2 | |
| SCHEMBL26012427 | 0.76 | SIGMAR1 (0.37) | SIGMAR1ADRA2APRCPKCNH2 | |
| SCHEMBL26012483 | 0.75 | DRD4 (0.45) | PRCPKCNH2 | |
| SCHEMBL26002308 | 0.72 | IP6K1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |