Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.48 |
| ▸ | PRCP | P42785 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26004354 | 0.87 | SIGMAR1 (0.49) | SIGMAR1PRCPKDM4EALDH1A1 | |
| SCHEMBL26014956 | 0.84 | SIGMAR1 (0.46) | SIGMAR1PRCP | |
| SCHEMBL26004590 | 0.83 | SIGMAR1 (0.46) | SIGMAR1PRCP | |
| SCHEMBL26004667 | 0.83 | SIGMAR1 (0.45) | SIGMAR1PRCP | |
| SCHEMBL26014541 | 0.83 | SIGMAR1 (0.45) | SIGMAR1PRCP | |
| SCHEMBL26004428 | 0.83 | SIGMAR1 (0.48) | SIGMAR1OPRD1CHRM2CHRM3 | |
| SCHEMBL26004734 | 0.83 | SIGMAR1 (0.46) | SIGMAR1PRCPKDM4E | |
| SCHEMBL26013583 | 0.83 | SIGMAR1 (0.46) | SIGMAR1PRCPALDH1A1OPRD1DRD2 | |
| SCHEMBL26004355 | 0.83 | SIGMAR1 (0.44) | SIGMAR1PRCPOPRD1 | |
| SCHEMBL26015090 | 0.83 | SIGMAR1 (0.44) | SIGMAR1PRCPOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |