SCHEMBL26015972

SCHEMBL26015972

Nc1nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)OCCNC(=O)CCCc4ccc(I)cc4)C(=O)O)cc3)c2c(=O)[nH]1

nearest known ligand 0.67

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ GART P22102 8/20 0.67
▸ FOLR1 P15328 7/20 0.67
▸ SLC46A1 Q96NT5 7/20 0.67
▸ SLC19A1 P41440 6/20 0.67
▸ TYMS P04818 5/20 0.67
▸ DHFR P00374 4/20 0.67
▸ FOLR2 P14207 3/20 0.67
▸ ATIC P31939 2/20 0.67
▸ SHMT1 P34896 1/20 0.67
▸ FRK P42685 1/20 0.67
▸ ALB P02768 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26015979 0.92 GART (0.73) GARTFOLR1SLC46A1SLC19A1TYMS
SCHEMBL25439555 0.88 GART (0.68) GARTFOLR1SLC46A1SLC19A1TYMS
SCHEMBL26015929 0.85 GART (0.73) GARTFOLR1SLC46A1SLC19A1TYMS
SCHEMBL19933020 0.85 GART (0.70) GARTFOLR1SLC46A1SLC19A1TYMS
SCHEMBL15145417 0.83 GART (0.72) GARTFOLR1SLC46A1SLC19A1TYMS
SCHEMBL15161119 0.83 GART (0.72) GARTFOLR1SLC46A1SLC19A1TYMS
SCHEMBL15161027 0.83 GART (0.74) GARTFOLR1SLC46A1SLC19A1TYMS
SCHEMBL15161026 0.83 GART (0.84) GARTFOLR1SLC46A1SLC19A1TYMS
SCHEMBL15078817 0.83 GART (0.84) GARTFOLR1SLC46A1SLC19A1TYMS
SCHEMBL464379 0.82 GART (0.70) GARTFOLR1SLC46A1SLC19A1TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250082657-A1 CONJUGATES OF CHEMOTHERAPY AGENTS AND TISSUE-BINDING SMALL MOLECULES, COMPOSITIONS AND METHODS THEREOF CANWELL BIOTECH LTD (CN) 2025-03-13 — — US disclosed
WO-2023150899-A1 CONJUGATES OF CHEMOTHERAPY AGENTS AND TISSUE-BINDING SMALL MOLECULES, COMPOSITIONS AND METHODS THEREOF CANWELL BIOTECH LIMITED (CN) 2023-08-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250082657-A1 CONJUGATES OF CHEMOTHERAPY AGENTS AND TISSUE-BINDING SMALL MOLECULES, COMPOSITIONS AND METHODS THEREOF FCGR2A, FCGR3B, CD44 GART 3120/4885FOLR1 43/4885SLC46A1 352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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