Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11200245 | 0.78 | LMNA (0.45) | KMT2AMEN1KCNQ2TAS1R3TAS1R1 | |
| SCHEMBL25438138 | 0.77 | IDO1 (0.42) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL29067546 | 0.76 | KCNQ2 (0.38) | KMT2AMEN1KCNQ2TAS1R3TAS1R1 | |
| SCHEMBL28160201 | 0.73 | KCNQ2 (0.45) | KMT2AMEN1KCNQ2TAS1R3TAS1R1 | |
| SCHEMBL11520827 | 0.72 | KCNQ2 (0.44) | KMT2AMEN1KCNQ2TAS1R3TAS1R1 | |
| Chlorobenzene SCHEMBL27650815 | 0.72 | MAPT (0.49) | KMT2AMEN1KCNQ2ALDH1A1MAPT | |
| SCHEMBL3228979 | 0.71 | TDP1 (0.46) | KMT2AMEN1KCNQ2TAS1R3TAS1R1 | |
| SCHEMBL13446854 | 0.71 | MAPT (0.48) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| Ammonia Solution, Strong SCHEMBL3225266 | 0.70 | NR4A2 (0.45) | KMT2AMEN1KCNQ2TAS1R3TAS1R1 | |
| SCHEMBL2082671 | 0.69 | LMNA (0.46) | KMT2AMEN1KCNQ2TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |