Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | SHH | Q15465 | 1/20 | 0.50 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.50 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26037196 | 0.89 | HPGD (0.48) | HPGDKMT2AMEN1MAPK14CDK9 | |
| SCHEMBL26037289 | 0.88 | MAPK14 (0.48) | HPGDKMT2AMAPK14NPC1RAB9A | |
| SCHEMBL2611893 | 0.88 | ALB (0.65) | HPGDNAMPTKMT2AMEN1ALB | |
| SCHEMBL26034631 | 0.86 | MAPK14 (0.48) | KMT2AMAPK14NPC1RAB9AALB | |
| SCHEMBL26034762 | 0.86 | KMT2A (0.48) | KMT2AMEN1MAPK14NPC1RAB9A | |
| SCHEMBL26036139 | 0.86 | CA2 (0.56) | KMT2AMEN1MAPK14NPC1RAB9A | |
| SCHEMBL26037383 | 0.84 | DRD3 (0.66) | KMT2AMEN1ALBHTR1ASLC6A2 | |
| SCHEMBL26035101 | 0.84 | ALB (0.50) | KMT2AMAPK14NPC1RAB9AALB | |
| SCHEMBL26037249 | 0.82 | NPC1 (0.50) | KMT2AMAPK14NPC1RAB9A | |
| SCHEMBL26037456 | 0.82 | KDM4A (0.50) | KMT2AMAPK14NPC1RAB9AALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | HPGD 2728/4885NAMPT 2382/4885KMT2A 1528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.