Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.53 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3777315 | 0.79 | KCNH2 (0.63) | POLBFFAR2ANO1KCNH2MEN1 | |
| SCHEMBL8125417 | 0.76 | SCD (0.64) | FFAR2ANO1KCNH2MEN1GAA | |
| SCHEMBL3616689 | 0.75 | KCNH2 (0.53) | POLBFFAR2ANO1KCNH2MEN1 | |
| SCHEMBL14047971 | 0.75 | FFAR2 (0.60) | POLBFFAR2ANO1KCNH2MEN1 | |
| SCHEMBL7130372 | 0.75 | PPARG (0.63) | MEN1KMT2AFBP1PKMSMN1; SMN2 | |
| SCHEMBL11434478 | 0.74 | HDAC1 (0.60) | FFAR2ANO1KCNH2MEN1GAA | |
| SCHEMBL5091405 | 0.74 | TP53 (0.64) | POLBFFAR2ANO1KCNH2MEN1 | |
| SCHEMBL3607740 | 0.74 | MAPT (0.52) | POLBFFAR2KCNH2MEN1GAA | |
| SCHEMBL4858645 | 0.73 | ANO1 (0.63) | POLBFFAR2ANO1KCNH2MEN1 | |
| SCHEMBL13471604 | 0.73 | FFAR2 (0.52) | POLBFFAR2ANO1KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159248-A1 | RE-SENSITIZING MULTIDRUG-RESISTANT (MDR) GRAM-NEGATIVE BACTERIA TO COLISTIN USING IONOPHORES | THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) | 2023-08-24 | — | — | WO | disclosed |