Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2619785 | 0.91 | ATM (0.54) | ATMPOLBALDH1A1TAAR1MAPT | |
| SCHEMBL1018147 | 0.91 | ATM (0.54) | ATMPOLBALDH1A1TAAR1MAPT | |
| SCHEMBL26035561 | 0.81 | MAPK14 (0.47) | MAPK14NPC1RAB9AKMT2A | |
| SCHEMBL5603888 | 0.81 | RAB9A (0.57) | ATMPOLBALDH1A1MAPTMAPK14 | |
| SCHEMBL26035579 | 0.81 | NPC1 (0.55) | MAPK14NPC1RAB9AKMT2A | |
| SCHEMBL26035544 | 0.81 | MAPK14 (0.47) | MAPK14NPC1RAB9AKDM4EKMT2A | |
| SCHEMBL26037249 | 0.80 | NPC1 (0.50) | MAPK14NPC1RAB9AKMT2A | |
| SCHEMBL26035513 | 0.79 | TRPV1 (0.47) | MAPK14NPC1RAB9AKMT2A | |
| SCHEMBL26035536 | 0.79 | MAPK14 (0.45) | MAPK14NPC1RAB9AKMT2A | |
| SCHEMBL26035527 | 0.78 | MAPK14 (0.44) | MAPK14HPGDNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | ATM 865/4885POLB 4447/4885ALDH1A1 2407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.