SCHEMBL26037582

SCHEMBL26037582

Cc1ccc(Nc2ccc(-c3ccc(Nc4ccc(C)cc4)cc3C(F)(F)F)c(C(F)(F)F)c2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 2/20 0.49
RAPGEF4 Q8WZA2 2/20 0.47
HPGD P15428 1/20 0.45
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
AKR1C3 P42330 1/20 0.43
AKR1C2 P52895 1/20 0.43
FFAR4 Q5NUL3 1/20 0.43
NPC1 O15118 1/20 0.43
MAPT P10636 1/20 0.43
HTT P42858 1/20 0.43
RAB9A P51151 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
GAA P10253 2/20 0.43
G6PD P11413 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
CYP17A1 P05093 1/20 0.43
GLA P06280 1/20 0.42
POLB P06746 1/20 0.42
TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4558336 0.83 PDK2 (0.51) APPHPGDMEN1KMT2AMAPT
SCHEMBL15931134 0.82 GLA (0.54) HPGDMEN1KMT2AAKR1C3AKR1C2
SCHEMBL10030392 0.78 GLA (0.54) AKR1C3AKR1C2FFAR4GAAGLA
SCHEMBL18858417 0.76 RAPGEF4 (0.40) APPRAPGEF4HPGDMEN1KMT2A
SCHEMBL15724709 0.76 MAPK1 (0.59) HTTGLATSHRMAPK1
SCHEMBL24219958 0.75 AR (0.42) RAPGEF4AKR1C3AKR1C2GAAL3MBTL1
SCHEMBL23560453 0.75 GLA (0.49) AKR1C3AKR1C2MAPTHTTGAA
SCHEMBL1981416 0.74 HPGD (0.54) APPHPGDMEN1KMT2AMAPT
SCHEMBL23074044 0.74 GLA (0.56) RAPGEF4AKR1C3AKR1C2MAPTHTT
SCHEMBL20697793 0.74 TSHR (0.42) AKR1C3AKR1C2GAAL3MBTL1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11732134-B2 Benzocyclobutene-containing polyimide resin and its composition, manufacturing method, redistribution layer, polyimide film, and use CHIN YEE CHEMICAL INDUSTRIES CO., LTD. (TW) 2023-08-22 US disclosed