Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26039316 | 0.89 | SIGMAR1 (0.31) | SIGMAR1 | |
| SCHEMBL26039573 | 0.89 | SIGMAR1 (0.31) | SIGMAR1 | |
| SCHEMBL25357235 | 0.88 | SIGMAR1 (0.34) | SIGMAR1KCNH2 | |
| SCHEMBL26052448 | 0.88 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL31387379 | 0.88 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL26047461 | 0.88 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL25357848 | 0.88 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL25355626 | 0.88 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL25356091 | 0.88 | SIGMAR1 (0.30) | SIGMAR1 | |
| SCHEMBL26039698 | 0.88 | SIGMAR1 (0.30) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |