Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | CA12 | O43570 | 5/20 | 0.50 |
| ▸ | CA6 | P23280 | 5/20 | 0.50 |
| ▸ | CA7 | P43166 | 5/20 | 0.50 |
| ▸ | CA9 | Q16790 | 5/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA4 | P22748 | 4/20 | 0.50 |
| ▸ | CA5A | P35218 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CASP2 | P42575 | 2/20 | 0.50 |
| ▸ | F13A1 | P00488 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | THPO | P40225 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24475227 | 0.98 | TDP1 (0.63) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL27410216 | 0.92 | TDP1 (0.55) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL15569541 | 0.86 | TDP1 (0.71) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL8403861 | 0.82 | CYP2C19 (0.62) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL4454481 | 0.82 | TDP1 (0.59) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL18263760 | 0.81 | TDP1 (0.62) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL2426477 | 0.81 | — | — | |
| SCHEMBL10939090 | 0.81 | TDP1 (0.57) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL19966296 | 0.80 | TDP1 (0.40) | TDP1ALOX15MEN1KMT2ACYP1A2 | |
| SCHEMBL323710 | 0.80 | TDP1 (0.61) | TDP1CA12CA6CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796753-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2017-10-24 | — | — | US | disclosed |
| US-9796753-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2017-10-24 | — | — | US | disclosed |
| EP-3112349-A2 | A PROCESS FOR PREPARING N-SUBSTITUTED INDENOISOQUINOLINES | Purdue Research Foundation (US) | 2017-01-04 | — | — | EP | disclosed |
| US-20160229888-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-08-11 | — | — | US | disclosed |
| US-20160229888-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-08-11 | — | — | US | disclosed |
| US-9399660-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2016-07-26 | — | — | US | disclosed |
| US-9399660-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2016-07-26 | — | — | US | disclosed |
| EP-1960366-B1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2016-07-20 | — | — | EP | disclosed |
| US-9388211-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2016-07-12 | — | — | US | disclosed |
| US-9388211-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2016-07-12 | — | — | US | disclosed |
| US-8829022-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2014-09-09 | — | — | US | disclosed |
| US-20120101119-A1 | N-substituted indenoisoquinolines and syntheses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-04-26 | — | — | US | disclosed |
| US-20120101119-A1 | N-substituted indenoisoquinolines and syntheses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-04-26 | — | — | US | disclosed |
| US-8053443-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2011-11-08 | — | — | US | disclosed |
| US-8053443-B2 | N-substituted indenoisoquinolines and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2011-11-08 | — | — | US | disclosed |
| US-20080318995-A1 | N-Substituted Indenoisoquinolines and Syntheses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-25 | — | — | US | disclosed |
| US-20080318995-A1 | N-Substituted Indenoisoquinolines and Syntheses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-25 | — | — | US | disclosed |
| EP-0166015-B1 | FLUORCARBON ANION EXCHANGERS AND PROCESSES FOR THEIR PREPARATION | Tosoh Corporation (JP) | 1988-12-28 | — | — | EP | disclosed |
| US-4659744-A | CATIONIC POLYMER CONTAINING SULFONAMIDE GROUPS AND QUATERNARY AMMONIUM SALTS | TOYO SODA MANUFACTURING CO., LTD. (JP) | 1987-04-21 | — | — | US | disclosed |
| EP-0166015-A1 | Fluorcarbon anion exchangers and processes for their preparation | Tosoh Corporation (JP) | 1986-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318995-A1 | N-Substituted Indenoisoquinolines and Syntheses Thereof | GNAQ, NRAS, NPM1 | TDP1 1868/4885CA12 4854/4885CA6 4377/4885 |
| US-20120101119-A1 | N-substituted indenoisoquinolines and syntheses thereof | GNAQ, NRAS, NPM1 | TDP1 1868/4885CA12 4854/4885CA6 4377/4885 |
| US-20160229888-A1 | N-SUBSTITUTED INDENOISOQUINOLINES AND SYNTHESES THEREOF | GNAQ, NRAS, NPM1 | TDP1 1868/4885CA12 4854/4885CA6 4377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.