GNAQ

Guanine nucleotide-binding protein G(q) subunit alpha · P50148 · GNAQ on Sugi Atlas →

296 patent compounds predicted against GNAQ, 155 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL13820269 SCHEMBL13820269 1.00 3/20
SCHEMBL14361129 SCHEMBL14361129 1.00 3/20
SCHEMBL22133450 SCHEMBL22133450 1.00 3/20
SCHEMBL22139627 SCHEMBL22139627 1.00 3/20
SCHEMBL22404881 SCHEMBL22404881 1.00 3/20
SCHEMBL22404883 SCHEMBL22404883 1.00 3/20
SCHEMBL26118416 SCHEMBL26118416 1.00 3/20
SCHEMBL26121610 SCHEMBL26121610 1.00 3/20
SCHEMBL22139625 SCHEMBL22139625 0.93 3/20
SCHEMBL29587750 SCHEMBL29587750 0.93 3/20
SCHEMBL29799481 SCHEMBL29799481 0.92 3/20
SCHEMBL22139591 SCHEMBL22139591 0.90 3/20
SCHEMBL29884447 SCHEMBL29884447 0.90 3/20
SCHEMBL22133305 SCHEMBL22133305 0.90 3/20
SCHEMBL29540174 SCHEMBL29540174 0.90 3/20
SCHEMBL29393036 SCHEMBL29393036 0.89 3/20
SCHEMBL22133449 SCHEMBL22133449 0.87 3/20
SCHEMBL22133467 SCHEMBL22133467 0.87 3/20
SCHEMBL22133302 SCHEMBL22133302 0.86 3/20
SCHEMBL29375264 SCHEMBL29375264 0.86 3/20

Clinical trials — most relevant to GNAQ by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
Safety and Efficacy of GS-100 Gene Therapy in Patients With NGLY1 Deficiency PHASE3ACTIVE_NOT_RECRUITING
PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome PHASE1/PHASE2COMPLETED
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas PHASE2COMPLETED
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients PHASE1/PHASE2COMPLETED
ADH1 and ADH2 Disease Monitoring Study (DMS) nanACTIVE_NOT_RECRUITING
Thrombin Regulated Platelet Activation nanCOMPLETED
Histamine Responsiveness in McCune-Albright Syndrome nanCOMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein nanCOMPLETED
Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography nanACTIVE_NOT_RECRUITING
GNE-Myopathy Disease Monitoring Program (GNEM-DMP): A Registry and Prospective Observational Natural History Study to Assess GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM) nanCOMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Clinical, Radiological, Histologic and Molecular Features of a Cohort of Melanocytic Tumors of the Central Nervous System nanUNKNOWN
GNAO1 Natural History Study nanUNKNOWN
Study of Adrenal Gland Tumors nanCOMPLETED
Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright Syndrome nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Evaluation of rhGH Replacement Therapy in Patients With Pseudohypoparathyroidism Type Ia (PHP Ia) nanUNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism. nanNOT_YET_RECRUITING
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients nanRECRUITING
A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases nanCOMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Rehabilitation Program in Patients With Acromegaly nanUNKNOWN
Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor. nanUNKNOWN
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo) nanWITHDRAWN
Incidental Genomics nanACTIVE_NOT_RECRUITING
An Investigation of Small Intestinal Carcinoid Carcinoma in Families nanUNKNOWN
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a GNAQ binder may also engage these)

ProteinNameSimilarity
Q2PKF4 1.000 Q2PKF4 →
P82471 1.000 P82471 →
Q28294 1.000 Q28294 →
P21279 1.000 P21279 →
P43444 1.000 P43444 →
P38410 1.000 P38410 →
Q2XSV9 1.000 Q2XSV9 →
P38409 1.000 P38409 →
P45645 1.000 P45645 →
P30677 1.000 P30677 →
Q9JID2 1.000 Q9JID2 →
P91950 1.000 P91950 →
P38411 1.000 P38411 →
P21278 1.000 P21278 →
GNA11 Guanine nucleotide-binding protein subunit alpha-11 1.000 landscape →
O95837 1.000 O95837 →
O15975 1.000 O15975 →
Q9BIG5 1.000 Q9BIG5 →
P38412 1.000 P38412 →
P20612 1.000 P20612 →
P0C7Q4 1.000 P0C7Q4 →
P04695 1.000 P04695 →
P19086 1.000 P19086 →
P38408 0.999 P38408 →
O70443 0.999 O70443 →
P30678 0.997 P30678 →
P91907 0.997 P91907 →
P34042 0.997 P34042 →
P87033 0.997 P87033 →
Q18434 0.997 Q18434 →