Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2600778 | 0.92 | SIRT5 (0.50) | SIRT5CA1CA2HDAC4HDAC1 | |
| SCHEMBL14615744 | 0.92 | SIRT5 (0.50) | SIRT5CA1CA2HDAC4HDAC1 | |
| SCHEMBL20067639 | 0.85 | CA1 (0.64) | SIRT5CA1CA2HDAC4HDAC1 | |
| SCHEMBL3496030 | 0.85 | SIRT5 (0.48) | SIRT5CA1CA2HDAC4HDAC1 | |
| SCHEMBL3496034 | 0.85 | SIRT5 (0.48) | SIRT5CA1CA2HDAC4HDAC1 | |
| SCHEMBL14378788 | 0.82 | CA1 (0.59) | SIRT5CA1CA2HDAC4HDAC1 | |
| SCHEMBL25935470 | 0.82 | HDAC4 (0.52) | SIRT5CA1CA2HDAC4HDAC1 | |
| SCHEMBL25935462 | 0.82 | HDAC4 (0.52) | SIRT5CA1CA2HDAC4HDAC1 | |
| SCHEMBL16847608 | 0.81 | MAPT (0.49) | SIRT5CA1CA2KDM4EMAPT | |
| SCHEMBL19017845 | 0.81 | MAPT (0.49) | SIRT5CA1CA2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163701-B2 | Prodrugs of active agents | SIGNATURE THERAPEUTICS, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20070123468-A1 | Prodrugs of active agents | PHARMACOFORE, INC. | 2007-05-31 | — | — | US | disclosed |
| US-20070123468-A1 | Prodrugs of active agents | PHARMACOFORE, INC. | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123468-A1 | Prodrugs of active agents | PAICS, AADAC, NQO1 | SIRT5 984/4885CA1 822/4885CA2 1647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.