Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24126281 | 0.84 | HRH3 (0.54) | HRH3GRM1GPR119DHFRCHIA | |
| SCHEMBL10150978 | 0.81 | GRIN2D (0.45) | HRH3GPR119DHFRHTR1ADRD4 | |
| SCHEMBL26048823 | 0.81 | GRM1 (0.47) | HRH3GRM1GPR119HCRTR1HCRTR2 | |
| SCHEMBL10121068 | 0.80 | ACACB (0.49) | ACACB | |
| SCHEMBL24434712 | 0.78 | HRH3 (0.46) | HRH3GPR119HCRTR1HCRTR2DHFR | |
| SCHEMBL20064022 | 0.77 | GRM1 (0.47) | HRH3GRM1GPR119HCRTR1HCRTR2 | |
| SCHEMBL23019809 | 0.77 | KMT2A (0.51) | GRM1GPR119HCRTR1HCRTR2CHIA | |
| SCHEMBL23046561 | 0.77 | GRM1 (0.44) | HRH3GRM1GPR119HCRTR1HCRTR2 | |
| SCHEMBL20004006 | 0.77 | KMT2A (0.51) | GRM1GPR119HCRTR1HCRTR2CHIA | |
| SCHEMBL20157231 | 0.75 | CHRNB4 (0.49) | GRM1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164235-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164236-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164237-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |