Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.72 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2605038 | 0.94 | HSP90AB1 (0.69) | HSP90AB1IKBKETBK1NUDT1TNKS | |
| SCHEMBL2605018 | 0.87 | HSP90AB1 (0.70) | HSP90AB1NUDT1TNKSGSK3BACHE | |
| SCHEMBL2605027 | 0.87 | HSP90AB1 (0.71) | HSP90AB1IKBKETBK1NUDT1TNKS | |
| SCHEMBL2605014 | 0.86 | HSP90AB1 (0.66) | HSP90AB1IKBKETBK1NUDT1TNKS | |
| SCHEMBL2077847 | 0.85 | HSP90AB1 (0.69) | HSP90AB1IKBKETBK1NUDT1TNKS | |
| SCHEMBL2605051 | 0.84 | HSP90AB1 (0.68) | HSP90AB1IKBKETBK1NUDT1TNKS | |
| SCHEMBL13437202 | 0.84 | HSP90AB1 (1.00) | HSP90AB1NUDT1TNKSGSK3BACHE | |
| SCHEMBL3556400 | 0.83 | HSP90AB1 (0.67) | HSP90AB1IKBKETBK1NUDT1TNKS | |
| SCHEMBL2606627 | 0.83 | HSP90AB1 (0.67) | HSP90AB1IKBKETBK1NUDT1TNKS | |
| SCHEMBL3556403 | 0.83 | HSP90AB1 (0.67) | HSP90AB1IKBKETBK1NUDT1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163750-B2 | Fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90 | SANOFI-AVENTIS (FR) | 2012-04-24 | — | — | US | disclosed |
| US-8163750-B2 | Fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90 | SANOFI-AVENTIS (FR) | 2012-04-24 | — | — | US | disclosed |
| US-20100130503-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | SANOFI-AVENTIS (FR) | 2010-05-27 | — | — | US | disclosed |
| US-20100130503-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | SANOFI-AVENTIS (FR) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130503-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | HSP90AB2P, HSPA2, HSP90AB1 | HSP90AB1 3/4885IKBKE 2193/4885TBK1 3859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.