Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11996623 | 0.83 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL10832921 | 0.82 | NR4A2 (0.46) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL10832926 | 0.82 | MAPK14 (0.45) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL5214925 | 0.76 | MAPK13 (0.58) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL2091239 | 0.75 | MAPK13 (0.83) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL15716348 | 0.73 | MAPK13 (0.54) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL5538991 | 0.73 | MAPK13 (0.54) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL31469380 | 0.73 | MAPK13 (0.54) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL18136485 | 0.70 | KDM4E (0.50) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL12270194 | 0.70 | GAA (0.47) | KDM4EGAASMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164237-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164233-A1 | (4-BENZO[D]OXAZOL-2-YL)-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-YL)METHANONE DERIVATIVES AS MUTANT PAH STABILIZERS FOR THE TREATMENT OF PHENYLKETONURIA | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |