Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26051044 | 0.82 | MAPK13 (0.51) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL11996623 | 0.76 | MAPK13 (0.46) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL10832921 | 0.75 | NR4A2 (0.46) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL10832865 | 0.73 | MAPK14 (0.39) | MAPK14CHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL5214925 | 0.70 | MAPK13 (0.58) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL27597513 | 0.69 | HPGD (0.43) | KMT2AGAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2091239 | 0.69 | MAPK13 (0.83) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL5210818 | 0.68 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL31194851 | 0.68 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11PTGS2 | |
| SCHEMBL15716348 | 0.67 | MAPK13 (0.54) | MAPK14MAPK13MAPK12MAPK11PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4596816-A | Pharmaceuticals | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-06-24 | — | — | US | disclosed |
| EP-0092239-A2 | Oxazole derivatives, production and use thereof | Takeda Chemical Industries, Ltd. (JP) | 1983-10-26 | — | — | EP | disclosed |