Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.39 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.33 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.33 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.33 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26051290 | 0.94 | ADRA1A (0.39) | ADRA1AHDAC6GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL26058750 | 0.94 | ADRA1A (0.39) | ADRA1AHDAC6GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL26052112 | 0.89 | HDAC6 (0.39) | ADRA1AHDAC6GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL26051179 | 0.88 | HDAC6 (0.38) | ADRA1AHDAC6GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL26051177 | 0.88 | HDAC6 (0.38) | ADRA1AHDAC6GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL26052166 | 0.87 | HDAC6 (0.38) | ADRA1AHDAC6GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL26057297 | 0.86 | HDAC6 (0.37) | ADRA1AHDAC6GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL26051041 | 0.86 | HDAC6 (0.44) | ADRA1AHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL26051345 | 0.84 | HDAC6 (0.36) | ADRA1AHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL26051042 | 0.83 | HDAC6 (0.42) | ADRA1AHDAC6GUCY1B2GUCY1A2GUCY1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150203-A1 | HDAC6 INHIBITORS AND USES THEREOF | EIKONIZO THERAPEUTICS, INC. (US) | 2023-08-10 | — | — | WO | disclosed |