Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CGAS | Q8N884 | 3/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597661 | 0.69 | CGAS (0.52) | ALDH1A1CGASCDK19ALKKDM4E | |
| SCHEMBL30839895 | 0.69 | CGAS (0.52) | ALDH1A1CGASCDK19ALKKDM4E | |
| SCHEMBL11545008 | 0.68 | ALDH1A1 (0.61) | ALDH1A1CGASCDK19ALKKDM4E | |
| SCHEMBL8608534 | 0.67 | CGAS (0.43) | TSHRALDH1A1CGASCDK19ALK | |
| SCHEMBL30404528 | 0.66 | CGAS (0.47) | ALDH1A1CGASCDK19ALKKDM4E | |
| SCHEMBL4651008 | 0.66 | CGAS (0.47) | ALDH1A1CGASCDK19ALKKDM4E | |
| SCHEMBL30158296 | 0.65 | ALDH1A1 (0.46) | ALDH1A1CGASCDK19ALKKDM4E | |
| SCHEMBL9848542 | 0.65 | ALDH1A1 (0.46) | ALDH1A1CGASCDK19ALKKDM4E | |
| SCHEMBL1832098 | 0.65 | ALDH1A1 (0.44) | ALDH1A1CGASCDK19ALKKDM4E | |
| SCHEMBL30158292 | 0.65 | ALDH1A1 (0.44) | ALDH1A1CGASCDK19ALKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3931188-B1 | NEW ISOINDOLINONE SUBSTITUTED INDOLES AND DERIVATIVES AS RAS INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2023-08-30 | — | — | EP | disclosed |