⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16310738 | 0.74 | KDM4E (0.44) | — | |
| SCHEMBL21189180 | 0.73 | — | — | |
| SCHEMBL3282357 | 0.73 | — | — | |
| SCHEMBL6404182 | 0.73 | — | — | |
| SCHEMBL3283129 | 0.73 | — | — | |
| SCHEMBL3280497 | 0.73 | — | — | |
| SCHEMBL14037823 | 0.73 | — | — | |
| SCHEMBL384468 | 0.72 | APLNR (0.43) | — | |
| SCHEMBL20162915 | 0.72 | PLAU (0.35) | — | |
| Hydrochloric Acid SCHEMBL11705118 | 0.71 | PLAU (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11505541-B2 | Protein kinase C inhibitors and methods of their use | NOVARTIS AG (CH) | 2022-11-22 | — | — | US | disclosed |
| US-20210387962-A1 | PROTEIN KINASE C INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2021-12-16 | — | — | US | disclosed |
| US-11180503-B2 | [1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives | ELI LILLY AND COMPANY (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200123154-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRAZIN-6(5H)-ONE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2020-04-23 | — | — | US | disclosed |
| US-20120095027-A1 | SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES | SPELMAN COLLEGE (US) | 2012-04-19 | — | — | US | disclosed |
| US-20120095009-A1 | SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES | SPELMAN COLLEGE (US) | 2012-04-19 | — | — | US | disclosed |