Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26041399 | 1.00 | SIGMAR1 (0.33) | SIGMAR1OPRL1 | |
| SCHEMBL26039316 | 0.87 | SIGMAR1 (0.31) | SIGMAR1 | |
| SCHEMBL26041400 | 0.85 | OPRL1 (0.33) | SIGMAR1OPRL1 | |
| SCHEMBL25359236 | 0.82 | OPRL1 (0.37) | SIGMAR1OPRL1 | |
| SCHEMBL25359241 | 0.82 | OPRL1 (0.37) | SIGMAR1OPRL1 | |
| SCHEMBL25355253 | 0.81 | OPRL1 (0.39) | OPRL1 | |
| SCHEMBL25358488 | 0.81 | OPRL1 (0.39) | OPRL1 | |
| SCHEMBL25355251 | 0.81 | OPRL1 (0.39) | OPRL1 | |
| SCHEMBL26039578 | 0.81 | — | — | |
| SCHEMBL31387389 | 0.81 | SIGMAR1 (0.34) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |