Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1161 | 0.98 | CYP3A4 (0.54) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL10562867 | 0.84 | SLC6A4 (0.51) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL9369667 | 0.82 | SLC6A4 (0.53) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL10564969 | 0.82 | CYP19A1 (0.49) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL10562244 | 0.80 | TRPV3 (0.52) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| Hydrochloric Acid SCHEMBL10559936 | 0.79 | TRPV3 (0.51) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL10564989 | 0.78 | SLC6A4 (0.49) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL10560720 | 0.76 | SLC6A4 (0.50) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL10560364 | 0.76 | SLC6A4 (0.50) | SLC6A4SLC6A3CYP3A4ALOX15TSHR | |
| SCHEMBL10623441 | 0.75 | SLC6A4 (0.89) | SLC6A4SLC6A3CYP3A4ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814352-A | ANTIDEPRESSANT CYCLOBUTYL BENZYLAMINE | THE BOOTS COMPANY PLC (GB) | 1989-03-21 | — | — | US | claimed |
| US-4746680-A | ANTIDEPRESSANTS | THE BOOTS COMPANY P.L.C. (GB) | 1988-05-24 | — | — | US | claimed |
| US-4522828-A | CYCLOBUTYLALKYLAMINE COMPOUNDS, ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1985-06-11 | — | — | US | claimed |
| US-4629727-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1986-12-16 | — | — | US | disclosed |
| EP-0111994-B1 | (1-ARYLCYCLOBUTYL) ALKYLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1986-02-26 | — | — | EP | disclosed |
| EP-0111994-A1 | (1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents | The Boots Company PLC (GB) | 1984-06-27 | — | — | EP | disclosed |