Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC8A1 | P32418 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.34 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL999388 | 0.85 | SLC8A1 (0.43) | SLC8A1LCKSMN1; SMN2MAPK14MAPK13 | |
| SCHEMBL999450 | 0.82 | CNR2 (0.44) | LCKSMN1; SMN2CNR2CCNE1CDK2 | |
| SCHEMBL1000283 | 0.80 | HDAC3 (0.40) | SLC8A1LCKSMN1; SMN2MAPK14CNR2 | |
| SCHEMBL1001793 | 0.78 | GCK (0.45) | LCKSMN1; SMN2MAPK14CNR2CCNE1 | |
| SCHEMBL999535 | 0.77 | FFAR2 (0.43) | LCKSMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL1000465 | 0.76 | APEX1 (0.43) | LCKMAPK14CCNE1CDK2CDK5 | |
| SCHEMBL999156 | 0.76 | LCK (0.39) | LCKSMN1; SMN2MAPK14MAPK13EGFR | |
| SCHEMBL999900 | 0.76 | GCK (0.47) | LCKSMN1; SMN2MAPK14NPC1GAA | |
| SCHEMBL999908 | 0.75 | HDAC3 (0.40) | SLC8A1LCKSMN1; SMN2MAPK14CNR2 | |
| SCHEMBL1000487 | 0.75 | GRM5 (0.45) | SLC8A1LCKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |