Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2606379 | 0.85 | EPHX1 (0.37) | ALDH1A1EPHX1EPHX2PDK2DPP4 | |
| SCHEMBL2606432 | 0.83 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MCHR1GPR119NPC1 | |
| SCHEMBL10273847 | 0.82 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MCHR1GPR119EPHX2 | |
| SCHEMBL2606450 | 0.81 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1EPHX1GPR119EPHX2 | |
| SCHEMBL2606417 | 0.79 | HPGD (0.42) | ALDH1A1L3MBTL1 | |
| SCHEMBL2606411 | 0.79 | MEN1 (0.42) | ALDH1A1L3MBTL1GPR119NPC1 | |
| SCHEMBL470951 | 0.79 | ALDH1A1 (0.48) | ALDH1A1EPHX1EPHX2DPP4DPP8 | |
| SCHEMBL2606479 | 0.78 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1MCHR1CYP3A4CYP2C9 | |
| SCHEMBL2606377 | 0.78 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1EPHX1EPHX2CYP3A4 | |
| SCHEMBL2606394 | 0.77 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |