Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | MAT2A | P31153 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25581842 | 0.80 | DHODH (0.34) | LRRK2MAPTKDM5BNPC1RAB9A | |
| SCHEMBL20086560 | 0.77 | LMNA (0.34) | POLBNPC1RAB9A | |
| SCHEMBL26482528 | 0.75 | S1PR2 (0.37) | LRRK2MAPTCRHR1 | |
| SCHEMBL25107870 | 0.74 | LRRK2 (0.33) | LRRK2 | |
| SCHEMBL21087670 | 0.74 | LRRK2 (0.40) | LRRK2POLBKMT2AGRM2CRHR1 | |
| SCHEMBL24828399 | 0.74 | LRRK2 (0.40) | LRRK2POLBKMT2AGRM2CRHR1 | |
| SCHEMBL24908121 | 0.73 | LRRK2 (0.40) | LRRK2KDM5B | |
| SCHEMBL26051306 | 0.73 | LRRK2 (0.40) | LRRK2POLBKMT2ACRHR1NPC1 | |
| SCHEMBL24828369 | 0.73 | LRRK2 (0.33) | LRRK2 | |
| SCHEMBL24828363 | 0.73 | LRRK2 (0.33) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164233-A1 | (4-BENZO[D]OXAZOL-2-YL)-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-YL)METHANONE DERIVATIVES AS MUTANT PAH STABILIZERS FOR THE TREATMENT OF PHENYLKETONURIA | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |