Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINA3 | P01011 | 1/20 | 0.47 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.41 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MGMT | P16455 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | POLA1 | P09884 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2606973 | 0.95 | SERPINA3 (0.51) | SERPINA3ADCY2HPRT1POLBMGMT | |
| SCHEMBL2607250 | 0.89 | SERPINA3 (0.45) | SERPINA3ADCY2HPRT1POLBMGMT | |
| SCHEMBL2607075 | 0.89 | SERPINA3 (0.49) | SERPINA3ADCY2HPRT1POLBMGMT | |
| SCHEMBL2606931 | 0.89 | SERPINA3 (0.50) | SERPINA3ADCY2HPRT1POLBMGMT | |
| SCHEMBL2734834 | 0.84 | POLB (0.58) | SERPINA3ADCY2HPRT1POLBHDAC1 | |
| SCHEMBL2606933 | 0.83 | SERPINA3 (0.49) | SERPINA3ADCY2HPRT1POLBMGMT | |
| SCHEMBL2606986 | 0.83 | SERPINA3 (0.51) | SERPINA3ADCY2HPRT1POLBMGMT | |
| SCHEMBL2734869 | 0.82 | SERPINA3 (0.48) | SERPINA3ADCY2HPRT1POLBHDAC1 | |
| SCHEMBL14621490 | 0.82 | SERPINA3 (0.48) | SERPINA3ADCY2HPRT1POLBHDAC1 | |
| SCHEMBL2606972 | 0.81 | POLB (0.45) | SERPINA3HPRT1POLBHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163718-B2 | Nucleoside analogues containing phosphonate or phosphonamide groups | GILEAD SCIENCES, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163718-B2 | Nucleoside analogues containing phosphonate or phosphonamide groups | GILEAD SCIENCES, INC. (US) | 2012-04-24 | — | — | US | disclosed |