Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983366 | 0.87 | ALDH1A1 (0.68) | ALDH1A1MAPTTSHRMAPK1TP53 | |
| SCHEMBL12297020 | 0.85 | ALDH1A1 (0.69) | ALDH1A1MAPTTSHRMAPK1TP53 | |
| SCHEMBL6983363 | 0.83 | ALDH1A1 (0.68) | ALDH1A1MAPTTSHRMAPK1TP53 | |
| SCHEMBL10039631 | 0.82 | ALDH1A1 (0.66) | ALDH1A1MAPTTSHRMAPK1TP53 | |
| SCHEMBL7400389 | 0.82 | ALDH1A1 (0.66) | ALDH1A1MAPTTSHRMAPK1TP53 | |
| SCHEMBL5605709 | 0.82 | ALDH1A1 (0.66) | POLBALDH1A1MAPTTSHRSMN1; SMN2 | |
| SCHEMBL10039555 | 0.82 | ALDH1A1 (0.58) | ALDH1A1MAPTTSHRMAPK1TP53 | |
| SCHEMBL1720494 | 0.81 | MAPT (0.72) | POLBALDH1A1MAPTTSHRGAA | |
| SCHEMBL2415496 | 0.81 | ALDH1A1 (0.64) | ALDH1A1MAPTTSHRMAPK1TP53 | |
| SCHEMBL5605913 | 0.81 | MAPT (0.69) | POLBALDH1A1MAPTTSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730152-B1 | TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-05-02 | — | — | EP | disclosed |
| US-8158640-B2 | Tetrahydroquinoline derivatives and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-04-17 | — | — | US | disclosed |
| US-8158640-B2 | Tetrahydroquinoline derivatives and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-04-17 | — | — | US | disclosed |
| US-20110039828-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-02-17 | — | — | US | disclosed |
| US-20110039828-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-02-17 | — | — | US | disclosed |
| US-7872126-B2 | Tetrahydroquinoline derivatives and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-01-18 | — | — | US | disclosed |
| US-7872126-B2 | Tetrahydroquinoline derivatives and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-01-18 | — | — | US | disclosed |
| US-20070082896-A1 | Tetrahydroquinoline derivatives and a process for preparing the same | TANABE SEIYAKU CO., LTD. | 2007-04-12 | — | — | US | disclosed |
| US-20070082896-A1 | Tetrahydroquinoline derivatives and a process for preparing the same | TANABE SEIYAKU CO., LTD. | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082896-A1 | Tetrahydroquinoline derivatives and a process for preparing the same | CETP, MTTP, NPC1L1 | POLB 3983/4885ALDH1A1 3895/4885MAPT 3634/4885 |
| US-20110039828-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | CETP, MTTP, NPC1L1 | POLB 3983/4885ALDH1A1 3895/4885MAPT 3634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.