Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 7/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | FLT1 | P17948 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27176104 | 0.82 | IDO1 (0.65) | IDO1HSP90AA1HSP90AB1ALDH1A1L3MBTL1 | |
| SCHEMBL29525253 | 0.78 | IDO1 (0.69) | IDO1S1PR1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL17498436 | 0.78 | IDO1 (0.69) | IDO1S1PR1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL25564684 | 0.77 | IDO1 (0.43) | IDO1S1PR1ALDH1A1L3MBTL1USP2 | |
| SCHEMBL29189522 | 0.76 | MAPT (0.39) | IDO1S1PR1ALDH1A1L3MBTL1HSD17B10 | |
| SCHEMBL27176094 | 0.75 | HPGD (0.49) | IDO1ALDH1A1L3MBTL1USP2HPGD | |
| SCHEMBL27176117 | 0.74 | SMN1; SMN2 (0.40) | IDO1ALDH1A1USP2HPGDHSD17B10 | |
| SCHEMBL27176100 | 0.74 | HSP90AA1 (0.51) | IDO1HSP90AA1HSP90AB1ALDH1A1L3MBTL1 | |
| SCHEMBL29189519 | 0.72 | IDO1 (0.43) | IDO1ALDH1A1MAPTLCK | |
| SCHEMBL30020374 | 0.72 | IDO1 (0.33) | IDO1S1PR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301096-A | Inhibitors of MYST family lysine acetyltransferase | 伊索斯泰里克斯公司 | 2025-01-10 | — | — | CN | disclosed |
| US-20240254139-A1 | FUSED ISOXAZOLYL COMPOUNDS AS KAT6A INHIBITORS | AURIGENE ONCOLOGY LTD (IN) | 2024-08-01 | — | — | US | disclosed |
| US-11976075-B2 | Inhibitors of the MYST family of lysine acetyl transferases | Isosterix, Inc. | 2024-05-07 | — | — | US | disclosed |
| US-11976075-B2 | Inhibitors of the MYST family of lysine acetyl transferases | Isosterix, Inc. | 2024-05-07 | — | — | US | disclosed |
| CN-117881677-A | Fused isoxazolyl compounds as KAT6Aw inhibitors | 奥瑞基尼肿瘤有限公司 | 2024-04-12 | — | — | CN | disclosed |
| EP-4341259-A1 | FUSED ISOXAZOLYL COMPOUNDS AS KAT6A INHIBITORS | Aurigene Oncology Limited (IN) | 2024-03-27 | — | — | EP | disclosed |
| WO-2023192817-A1 | INHIBITORS OF THE MYST FAMILY OF LYSINE ACETYL TRANSFERASES | Isosterix, Inc. (US) | 2023-10-05 | — | — | WO | disclosed |
| US-20230303580-A1 | INHIBITORS OF THE MYST FAMILY OF LYSINE ACETYL TRANSFERASES | Isosterix, Inc. | 2023-09-28 | — | — | US | disclosed |
| US-20230303580-A1 | INHIBITORS OF THE MYST FAMILY OF LYSINE ACETYL TRANSFERASES | Isosterix, Inc. | 2023-09-28 | — | — | US | disclosed |
| WO-2022243983-A1 | FUSED ISOXAZOLYL COMPOUNDS AS KAT6A INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303580-A1 | INHIBITORS OF THE MYST FAMILY OF LYSINE ACETYL TRANSFERASES | KAT6A, KAT6B, KAT2A | IDO1 3316/4885S1PR1 4146/4885HSP90AA1 1912/4885 |
| US-11976075-B2 | Inhibitors of the MYST family of lysine acetyl transferases | KAT6A, KAT6B, KAT2A | IDO1 3316/4885S1PR1 4146/4885HSP90AA1 1912/4885 |
| US-20240254139-A1 | FUSED ISOXAZOLYL COMPOUNDS AS KAT6A INHIBITORS | KAT6A, KAT6B, KAT2A | IDO1 1860/4885S1PR1 4448/4885HSP90AA1 632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.