Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | ESRRB | O95718 | 1/20 | 0.53 |
| ▸ | ESRRA | P11474 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26074746 | 0.94 | ESR1 (0.50) | ESR1ESR2ESRRBESRRAKDM4E | |
| SCHEMBL26074761 | 0.91 | NPC1 (0.47) | ESR1ESR2ESRRBESRRAKDM4E | |
| SCHEMBL26074769 | 0.91 | CHRNA7 (0.47) | ESR1ESR2ESRRBESRRAKDM4E | |
| SCHEMBL26074739 | 0.91 | CHRNA7 (0.44) | ESR1ESR2ESRRBESRRAKDM4E | |
| SCHEMBL26075536 | 0.90 | PLA2G2A (0.53) | ESR1ESR2ESRRBESRRAKDM4E | |
| SCHEMBL26075534 | 0.90 | PDE10A (0.54) | ESR1ESR2ESRRBESRRAPLA2G2A | |
| SCHEMBL26074127 | 0.90 | ESR1 (0.48) | ESR1ESR2ESRRBESRRAKDM4E | |
| SCHEMBL26075545 | 0.90 | DHODH (0.48) | ESR1ESR2ESRRBESRRAKDM4E | |
| SCHEMBL26075533 | 0.89 | PLA2G2A (0.63) | ESR1ESR2ESRRBESRRAKDM4E | |
| SCHEMBL26075540 | 0.88 | ESR1 (0.49) | ESR1ESR2ESRRBESRRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303710-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2023-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303710-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | DHODH, CD38, DPYD | ESR1 4427/4885ESR2 4530/4885ESRRB 4671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.