Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.44 |
| ▸ | ACP1 | P24666 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26075333 | 0.89 | DHODH (0.41) | DHODHACP1PDE10ADHFRALKBH5 | |
| SCHEMBL23590249 | 0.85 | DHODH (0.66) | DHODHALDH1A1HPGDPLA2G2A | |
| SCHEMBL26074118 | 0.82 | PLA2G2A (0.64) | DHODHALDH1A1PLA2G2A | |
| SCHEMBL26075571 | 0.82 | DHODH (0.45) | DHODHACP1ALDH1A1THRBHPGD | |
| SCHEMBL14700162 | 0.80 | DHODH (0.58) | DHODHACP1ALDH1A1THRBHPGD | |
| SCHEMBL26075138 | 0.79 | DHODH (0.41) | DHODHALDH1A1THRBHPGDDHFR | |
| SCHEMBL26075334 | 0.78 | PDE10A (0.39) | DHODHACP1PDE10ADHFRALKBH5 | |
| SCHEMBL26074087 | 0.77 | DHODH (0.47) | DHODHPDE10ADHFRALKBH5PLA2G2A | |
| SCHEMBL23590116 | 0.76 | DHODH (0.56) | DHODHPDE10AALDH1A1HPGDPLA2G2A | |
| SCHEMBL26075136 | 0.76 | ESR1 (0.50) | DHODHDHFRALKBH5TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303710-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2023-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303710-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | DHODH, CD38, DPYD | DHODH 1/4885ACP1 2245/4885PDE10A 3462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.