Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.82 |
| ▸ | JAK3 | P52333 | 20/20 | 0.82 |
| ▸ | JAK2 | O60674 | 15/20 | 0.82 |
| ▸ | JAK1 | P23458 | 15/20 | 0.82 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.72 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21229652 | 0.96 | TYK2 (0.78) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL23517233 | 0.96 | TYK2 (0.78) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL24337136 | 0.92 | TYK2 (0.78) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL23517261 | 0.90 | TYK2 (0.76) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL21574367 | 0.90 | TYK2 (1.00) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL21574361 | 0.90 | TYK2 (0.87) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL18269701 | 0.90 | TYK2 (1.00) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL22055028 | 0.90 | TYK2 (0.76) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL23889259 | 0.89 | TYK2 (0.74) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL21229893 | 0.89 | TYK2 (1.00) | TYK2JAK3JAK2JAK1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780852-B2 | Methods for treating Crohn's disease using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-10-10 | — | — | US | disclosed |
| US-11739103-B2 | Processes for preparing a pan-JAK inhibitor and related intermediate compounds | Theravance Biopharma R&D LP, LLC (US) | 2023-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780852-B2 | Methods for treating Crohn's disease using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile | ALPI, TPMT, SLC10A2 | TYK2 1776/4885JAK3 351/4885JAK2 1867/4885 |
| US-11739103-B2 | Processes for preparing a pan-JAK inhibitor and related intermediate compounds | JAK1, JAK3, JAK2 | TYK2 50/4885JAK3 2/4885JAK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.