Terofenamate

Terofenamate

SCHEMBL26088

CCOCOC(=O)c1ccccc1Nc1c(Cl)ccc(C)c1Cl

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METTL3 Q86U44 2/20 0.84
PTGS2 P35354 14/20 0.70
MEN1 O00255 2/20 0.62
MAPK1 P28482 2/20 0.62
KMT2A Q03164 2/20 0.62
AKR1B10 O60218 1/20 0.62
ABCB11 O95342 1/20 0.62
TTR P02766 1/20 0.62
ADORA3 P0DMS8 1/20 0.62
CHRM1 P11229 1/20 0.62
FABP2 P12104 1/20 0.62
RXRA P19793 1/20 0.62
TBXA2R P21731 1/20 0.62
NR4A1 P22736 1/20 0.62
PTGS1 P23219 1/20 0.62
PDE4A P27815 1/20 0.62
AKR1C3 P42330 1/20 0.62
NR4A2 P43354 1/20 0.62
AKR1C2 P52895 1/20 0.62
AKR1C1 Q04828 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Terofenamate SCHEMBL29483481 1.00 METTL3 (0.84) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL15537603 0.99 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL14247884 0.99 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL6851974 0.99 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL1671593 0.99 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL15538328 0.99 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL49245 0.99 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL7636015 0.99 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL22612217 0.99 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A
Terofenamate SCHEMBL3241449 0.99 METTL3 (0.83) METTL3PTGS2MEN1MAPK1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2151 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240041935-A1 PREVENTION AND TREATMENT OF REPRODUCTIVE FAILURE BY REGENERATIVE CELLS AND ADJUVANTS CREATIVE MEDICAL TECHNOLOGIES, INC. (US) 2024-02-08 US claimed
CN-114965774-A Method for detecting residues of 208 pesticides and metabolites thereof in aquatic products 江苏省淡水水产研究所 2022-08-30 CN claimed
EP-4034087-A1 LIPID VESICLE COMPOSITIONS WITH PENETRATION ENHANCING AGENTS DDS Research Inc. (CA) 2022-08-03 EP claimed
US-20220218611-A1 LIPID VESICLE COMPOSITIONS WITH PENETRATION ENHANCING AGENTS DDS RESEARCH INC. (CA) 2022-07-14 US claimed
CN-108473508-B Heterocyclic substituted bicyclic azole insecticides FMC公司 2021-11-30 CN claimed
CN-112834647-A Method for determining 297 pesticide residues by combining pretreatment technology of high-oil complex matrix sample with GC-MSMS (gas chromatography-metal-semiconductor mass spectrometry) 中国检验检疫科学研究院 2021-05-25 CN claimed
WO-2021056106-A1 LIPID VESICLE COMPOSITIONS WITH PENETRATION ENHANCING AGENTS DDS RESEARCH INC. (CA) 2021-04-01 WO claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-8865198-B2 Method for treating a periodontal disease DEXCEL PHARMA TECHNOLOGIES LTD. (IL) 2014-10-21 US claimed
US-20130116211-A1 Novel Salts Of Boswellic Acids And Selectively Enriched Boswellic Acids And Processes For The Same GOKARAJU GANGA RAJU (IN) 2013-05-09 US claimed
EP-0792371-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-09-03 EP claimed
EP-0786999-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-08-06 EP claimed
EP-0759750-A1 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO, Howard, K. (US) 1997-03-05 EP claimed
US-5543417-A 5 Alpha-reductase inhibitor and at least one of an antibacterial agent, a keratolytic agent or an anti-inflammatory agent MERCK & CO., INC. (US) 1996-08-06 US claimed
WO-1996012487-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO claimed
WO-1996012817-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO claimed
WO-1995031194-A1 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO HOWARD K (US) 1995-11-23 WO claimed
EP-0130524-B1 DEPOT ANTIPHLOGISTICS Troponwerke GmbH & Co. KG (DE) 1989-08-23 EP claimed
US-4594357-A Depot antiinflammatory agents TROPONWERKE GMBH & CO. (DE) 1986-06-10 US claimed
EP-0130524-A2 Depot antiphlogistics Troponwerke GmbH & Co. KG (DE) 1985-01-09 EP claimed