Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 10/20 | 0.75 |
| ▸ | IGF1R | P08069 | 10/20 | 0.75 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.75 |
| ▸ | EGFR | P00533 | 11/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | STK10 | O94804 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | CD74 | P04233 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.65 |
| ▸ | FES | P07332 | 1/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | YES1 | P07947 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30378071 | 1.00 | INSR (0.75) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL26089363 | 0.90 | INSR (0.77) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL15217790 | 0.86 | INSR (1.00) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL30378164 | 0.84 | INSR (0.79) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL26089861 | 0.84 | ALK (1.00) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL24327435 | 0.83 | ALK (0.77) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL30378262 | 0.83 | ALK (0.77) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL26090325 | 0.83 | ALK (0.82) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL30378416 | 0.83 | INSR (0.64) | INSRIGF1RALKEGFRCHEK1 | |
| SCHEMBL26133857 | 0.83 | INSR (0.64) | INSRIGF1RALKEGFRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023070114-A2 | REVERSIBLE LYSINE COVALENT MODIFIERS OF EGFR AND USES THEREOF | TERREMOTO BIOSCIENCES, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023070114-A2 | REVERSIBLE LYSINE COVALENT MODIFIERS OF EGFR AND USES THEREOF | TERREMOTO BIOSCIENCES, INC. (US) | 2023-04-27 | — | — | WO | disclosed |