Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 16/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 14/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 14/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 14/20 | 0.47 |
| ▸ | CLK1 | P49759 | 9/20 | 0.47 |
| ▸ | CLK2 | P49760 | 9/20 | 0.47 |
| ▸ | CLK3 | P49761 | 9/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.47 |
| ▸ | DYRK4 | Q9NR20 | 9/20 | 0.47 |
| ▸ | GSK3B | P49841 | 7/20 | 0.47 |
| ▸ | PIM1 | P11309 | 6/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 6/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 6/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 6/20 | 0.47 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30494021 | 1.00 | DYRK1A (0.47) | DYRK1ADYRK3DYRK2DYRK1BCLK1 | |
| SCHEMBL29899892 | 0.87 | DYRK1A (0.62) | DYRK1ADYRK3DYRK2DYRK1BCLK1 | |
| SCHEMBL28842956 | 0.87 | DYRK1A (0.62) | DYRK1ADYRK3DYRK2DYRK1BCLK1 | |
| SCHEMBL23499919 | 0.87 | DYRK1A (0.62) | DYRK1ADYRK3DYRK2DYRK1BCLK1 | |
| SCHEMBL30363437 | 0.82 | DYRK1A (0.53) | DYRK1ADYRK3DYRK2DYRK1BCLK1 | |
| SCHEMBL26094901 | 0.82 | DYRK1A (0.53) | DYRK1ADYRK3DYRK2DYRK1BCLK1 | |
| SCHEMBL30494070 | 0.81 | DYRK2 (0.46) | DYRK1ADYRK3DYRK2DYRK1BCLK1 | |
| SCHEMBL26093429 | 0.81 | DYRK2 (0.46) | DYRK1ADYRK3DYRK2DYRK1BCLK1 | |
| SCHEMBL26094020 | 0.80 | DYRK1A (0.46) | DYRK1ADYRK3DYRK2DYRK1BCLK1 | |
| SCHEMBL29899847 | 0.79 | DYRK1A (0.60) | DYRK1ADYRK3DYRK2DYRK1BCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250340539-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1, AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2025-11-06 | — | — | US | claimed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | claimed |
| EP-4173675-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-05-03 | — | — | EP | claimed |
| US-20250340539-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1, AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2025-11-06 | — | — | US | disclosed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |
| EP-4173675-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-05-03 | — | — | EP | disclosed |
| EP-4173675-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-05-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250340539-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1, AND/OR CLK4 | CLK1, CLK2, CLK3 | DYRK1A 20/4885DYRK3 125/4885DYRK2 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.