Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 10/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.46 |
| ▸ | PIM1 | P11309 | 5/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 4/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.37 |
| ▸ | CLK2 | P49760 | 3/20 | 0.37 |
| ▸ | CLK3 | P49761 | 3/20 | 0.37 |
| ▸ | DYRK4 | Q9NR20 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26093429 | 1.00 | DYRK2 (0.46) | DYRK2CDK5CDK5R1PIM1DYRK1A | |
| SCHEMBL26092571 | 0.81 | DYRK1A (0.47) | DYRK2CDK5CDK5R1PIM1DYRK1A | |
| SCHEMBL30494021 | 0.81 | DYRK1A (0.47) | DYRK2CDK5CDK5R1PIM1DYRK1A | |
| SCHEMBL26094360 | 0.81 | DYRK2 (0.45) | DYRK2CDK5CDK5R1PIM1DYRK1A | |
| SCHEMBL26092047 | 0.81 | DYRK2 (0.49) | DYRK2CDK5CDK5R1PIM1DYRK1A | |
| SCHEMBL30395543 | 0.81 | DYRK2 (0.49) | DYRK2CDK5CDK5R1PIM1DYRK1A | |
| SCHEMBL30494062 | 0.79 | DYRK2 (0.45) | DYRK2CDK5CDK5R1PIM1DYRK1A | |
| SCHEMBL30494158 | 0.79 | DYRK2 (0.45) | DYRK2CDK5CDK5R1PIM1DYRK1A | |
| SCHEMBL26095945 | 0.79 | DYRK2 (0.45) | DYRK2CDK5CDK5R1PIM1DYRK1A | |
| SCHEMBL26095122 | 0.79 | DYRK2 (0.45) | DYRK2CDK5CDK5R1PIM1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4422753-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | claimed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | claimed |
| EP-4422753-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |