Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18496770 | 1.00 | TSHR (0.41) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL16417088 | 1.00 | TSHR (0.41) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL26101999 | 1.00 | TSHR (0.41) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL19611876 | 1.00 | TSHR (0.41) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL24835739 | 0.87 | TSHR (0.50) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL30552236 | 0.87 | TSHR (0.50) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL31591142 | 0.87 | TSHR (0.50) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL23302849 | 0.86 | LMNA (0.40) | TSHRCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2346516 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL29132347 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |