Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of L-Norepinephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 4/20 | 1.00 |
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 1.00 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 1.00 |
| ▸ | ADRB3 known ✓ | P13945 | 3/20 | 1.00 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 1.00 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 1.00 |
| ▸ | BLM | P54132 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | RECQL | P46063 | 4/20 | 1.00 |
| ▸ | APEX1 | P27695 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Norepinephrine SCHEMBL3489077 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| L-Norepinephrine SCHEMBL29460319 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| L-Norepinephrine SCHEMBL29371849 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| Norepinephrine SCHEMBL29399946 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| Norepinephrine SCHEMBL2609 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| Norepinephrine SCHEMBL2429869 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| L-Norepinephrine SCHEMBL4155242 | 0.98 | BLM (0.96) | TDP1KDM4EBLMMAPTADRB2 | |
| Norepinephrine SCHEMBL10576062 | 0.98 | TDP1 (0.96) | TDP1KDM4EBLMMAPTADRB2 | |
| Norepinephrine SCHEMBL3334108 | 0.98 | TDP1 (0.96) | TDP1KDM4EBLMMAPTADRB2 | |
| L-Norepinephrine SCHEMBL17504429 | 0.98 | TDP1 (0.96) | TDP1KDM4EBLMMAPTADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 119873 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146967-A1 | DEVICE AND SENSOR FOR DETECTION OF AN ANALYTE | REMINDED, INC. (US) | 2026-05-28 | — | — | US | claimed |
| US-20260144903-A1 | RADIONUCLIDE-LABELED BORON-CONTAINING DRUG, AND PREPARATION AND USE THEREOF | Chengdu New Radiomedicine Technology Co., Ltd. (CN) | 2026-05-28 | — | — | US | claimed |
| US-20260144765-A1 | COMPOUNDS AND COMBINATIONS THEREOF FOR TREATING NEUROLOGICAL AND PSYCHIATRIC CONDITIONS | ANTECIP BIOVENTURES II LLC (US) | 2026-05-28 | — | — | US | claimed |
| US-20260145003-A1 | OCULAR PHOTO-BIO-STIMULATION | NeuroRays, LLC (US) | 2026-05-28 | — | — | US | claimed |
| EP-4749281-A2 | DETECTOR | UK NIVD Ltd (GB) | 2026-05-27 | — | — | EP | claimed |
| EP-4747247-A1 | NOVEL FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | Apogee Pharmaceuticals, Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| EP-4747627-A1 | METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS | Matterworks Inc (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122081102-A | Microbial strain for de novo synthesis of gardenia flavin B and application of microbial strain in production of polymethoxy flavonoid compound | — | 2026-05-26 | — | — | CN | claimed |
| CN-122084713-A | Microelectrode, probe and electrochemical detection device | — | 2026-05-26 | — | — | CN | claimed |
| EP-0005058-A2 | Composition for regulating dopamine or norepinephrine levels in neuronal synapses | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1979-10-31 | — | — | EP | claimed |
| US-4122078-A | Antigens and antibodies of catecholamines | DAIICHI SEIYAKU CO., LTD. (JP) | 1978-10-24 | — | — | US | claimed |
| US-4116949-A | WATER-SOLUBLE, PHYSIOLOGICALLY ACTIVE, SYNTHETIC COPOLYPEPTIDES | THE REAGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1978-09-26 | — | — | US | claimed |
| US-4108973-A | OXIDATION | HOFFMANN-LA ROCHE INC. (US) | 1978-08-22 | — | — | US | claimed |
| US-4097586-A | Immunochemical assay method | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1978-06-27 | — | — | US | claimed |
| US-4066747-A | Polymeric orthoesters housing beneficial drug for controlled release therefrom | ALZA CORPORATION (US) | 1978-01-03 | — | — | US | claimed |
| US-4053637-A | ANTIDEPRESSANTS | ASTRA LAKEMEDAL AKTIEBOLAG (SW) | 1977-10-11 | — | — | US | claimed |
| US-4016146-A | Phenethylamine antigenic conjugates, their preparation, antibodies, and use | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1977-04-05 | — | — | US | claimed |
| US-3977404-A | OSMOTIC DEVICE HAVING MICROPOROUS RESERVOIR | ALZA CORPORATION (US) | 1976-08-31 | — | — | US | claimed |
| US-3961060-A | DOPA, M-TYROSINE, APOMORPHINE, PIPERAZINE DERIVATIVE | ASTRA LAKEMEDAL AKTIEBOLAG (SW) | 1976-06-01 | — | — | US | claimed |