Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of L-Norepinephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 4/20 | 1.00 |
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 1.00 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 1.00 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 1.00 |
| ▸ | ADRB3 known ✓ | P13945 | 3/20 | 1.00 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 1.00 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 1.00 |
| ▸ | BLM | P54132 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | RECQL | P46063 | 4/20 | 1.00 |
| ▸ | APEX1 | P27695 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norepinephrine SCHEMBL2609 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| L-Norepinephrine SCHEMBL29460319 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| L-Norepinephrine SCHEMBL2610 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| Norepinephrine SCHEMBL29399946 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| L-Norepinephrine SCHEMBL3489077 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| Norepinephrine SCHEMBL2429869 | 1.00 | TDP1 (1.00) | TDP1KDM4EBLMMAPTADRB2 | |
| Norepinephrine SCHEMBL4155239 | 0.98 | TDP1 (0.96) | TDP1KDM4EBLMMAPTADRB2 | |
| Norepinephrine SCHEMBL3334108 | 0.98 | TDP1 (0.96) | TDP1KDM4EBLMMAPTADRB2 | |
| L-Norepinephrine SCHEMBL317206 | 0.98 | BLM (0.96) | TDP1KDM4EBLMMAPTADRB2 | |
| L-Norepinephrine SCHEMBL4155242 | 0.98 | BLM (0.96) | TDP1KDM4EBLMMAPTADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122031747-A | Mesoscopic phase enhanced polyphenol-based aggregate adhesive and preparation method thereof | 华南理工大学 | 2026-05-15 | — | — | CN | claimed |
| CN-120137487-A | Corrosion-resistant fracture-resistant steel structural member and processing technology thereof | 河北兆鹏建工有限公司 | 2025-06-13 | — | — | CN | claimed |
| CN-119431086-A | Multilayer microcapsule structure epsilon-CL-20 explosive crystal capable of resisting dissolution and inhibiting crystal transformation and preparation method | 北京理工大学 | 2025-02-14 | — | — | CN | claimed |
| CN-119265610-A | Carbon-coated porous high-entropy alloy nano-array catalyst and preparation method thereof | 惠州学院 | 2025-01-07 | — | — | CN | claimed |
| CN-118923830-A | Honey dew added with food ingredients and production process thereof | 武汉安孕堂创新科技有限公司 | 2024-11-12 | — | — | CN | claimed |
| CN-117229533-A | Anti-freezing hydrogel based on extracted grape residues and preparation method and application thereof | 鲁东大学 | 2023-12-15 | — | — | CN | claimed |
| CN-116666740-A | Composite material, preparation method thereof, solid electrolyte film and lithium battery | 浙江正泰电器股份有限公司 | 2023-08-29 | — | — | CN | claimed |
| CN-114479807-B | Organic nano particle/surfactant compound wetting agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2023-07-04 | — | — | CN | claimed |
| CN-114933835-B | Steel pipe anticorrosive coating and steel pipe using same | 河南亿阳管业科技有限公司 | 2023-04-28 | — | — | CN | claimed |
| CN-114933835-A | Steel pipe anticorrosive coating and steel pipe using same | 河南亿阳管业科技有限公司 | 2022-08-23 | — | — | CN | claimed |
| CN-113999710-B | Preparation method of nitrogen-doped carbon quantum dot reinforced hBN nano fluid lubricant | 北京科技大学 | 2022-08-02 | — | — | CN | claimed |
| CN-114479807-A | Organic nano-particle/surfactant compound wetting agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-112263706-B | Biodegradable biological adhesive and preparation method thereof | 苏州度博迈医疗科技有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-113999710-A | Preparation method of nitrogen-doped carbon quantum dot reinforced hBN nano fluid lubricant | 北京科技大学 | 2022-02-01 | — | — | CN | claimed |
| CN-122031747-A | Mesoscopic phase enhanced polyphenol-based aggregate adhesive and preparation method thereof | 华南理工大学 | 2026-05-15 | — | — | CN | disclosed |
| CN-120137487-A | Corrosion-resistant fracture-resistant steel structural member and processing technology thereof | 河北兆鹏建工有限公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-116162034-B | Racemic noradrenal gland chiral resolution method of element | 蚌埠丰原医药科技发展有限公司 | 2025-05-27 | — | — | CN | disclosed |
| CN-114479807-A | Organic nano-particle/surfactant compound wetting agent and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-113045415-B | Synthesis method of noradrenaline impurity | 南京仁为医药科技有限公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-113999710-A | Preparation method of nitrogen-doped carbon quantum dot reinforced hBN nano fluid lubricant | 北京科技大学 | 2022-02-01 | — | — | CN | disclosed |