Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.34 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 9/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26100954 | 0.93 | TYK2 (0.37) | TYK2ROCK1F10GPR52 | |
| SCHEMBL26099498 | 0.93 | GPR52 (0.35) | TYK2ROCK1F10GPR52 | |
| SCHEMBL26099530 | 0.92 | TYK2 (0.34) | TYK2ROCK1F10GPR52 | |
| SCHEMBL26100687 | 0.91 | TYK2 (0.34) | TYK2ROCK1F10GPR52 | |
| SCHEMBL26100675 | 0.89 | TYK2 (0.35) | TYK2ROCK1F10GPR52 | |
| SCHEMBL31161297 | 0.88 | TYK2 (0.34) | TYK2ROCK1F10GPR52 | |
| SCHEMBL26101093 | 0.86 | MAPT (0.34) | TYK2SMYD2F10 | |
| SCHEMBL30391637 | 0.86 | TYK2 (0.33) | TYK2ROCK1F10 | |
| SCHEMBL26099972 | 0.86 | TYK2 (0.33) | TYK2ROCK1F10 | |
| SCHEMBL26102480 | 0.85 | TYK2 (0.36) | TYK2ROCK1F10GPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |