GPR52 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1846847	0.77	18/20
SCHEMBL95417	0.53	18/20
SCHEMBL95418	0.53	18/20
SCHEMBL1846879	0.85	17/20
SCHEMBL96507	0.55	17/20
SCHEMBL96508	0.55	17/20
SCHEMBL97631	0.52	17/20
SCHEMBL96945	0.50	17/20
SCHEMBL96946	0.50	17/20
SCHEMBL146890	0.50	17/20
SCHEMBL1847051	0.89	16/20
SCHEMBL1846506	0.81	16/20
SCHEMBL1846908	0.78	16/20
SCHEMBL1268421	0.57	16/20
SCHEMBL1268422	0.57	16/20
SCHEMBL961978	1.00	15/20
SCHEMBL962167	0.71	14/20
SCHEMBL106847	0.55	12/20
SCHEMBL448516	0.55	12/20
SCHEMBL960922	0.81	11/20

Clinical trials — most relevant to GPR52 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Mediterranean Diet and Inequality in Early Breast Cancer	PHASE2	RECRUITING
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration	PHASE2	WITHDRAWN
Dose Ranging Study of Carbidopa-levodopa	PHASE2	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study	PHASE1	UNKNOWN
68Ga-NOTA-RM26 PET/CT in Prostate Cancer Patients	PHASE1	UNKNOWN
The Role of Endocannabinoids in Insulin Production and Action	PHASE1	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
Gastroparesis Registry 3	nan	COMPLETED
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors	nan	UNKNOWN
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease	nan	COMPLETED
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
The Severe Asthma Research Program III-Boston Clinical Site	nan	COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
The Role of Autoantibodies Against G-protein Coupled Receptors in Obesity	nan	NOT_YET_RECRUITING
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
Development of Therapeutic Approaches Modulating Molecular Targets Implicated on Cancer Stem Cell-related Aggressiveness	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a GPR52 binder may also engage these)

Protein	Name	Similarity
P0C5J4	—	1.000	P0C5J4 →
A6QLE7	—	1.000	A6QLE7 →
Q8BX79	—	0.997	Q8BX79 →
Q99679	—	0.996	Q99679 →
HTR4	5-hydroxytryptamine receptor 4	0.991	landscape →
P18901	—	0.991	P18901 →
P54833	—	0.990	P54833 →
O70528	—	0.990	O70528 →
P97288	—	0.989	P97288 →
Q4KWL2	—	0.989	Q4KWL2 →
P10608	—	0.988	P10608 →
P04274	—	0.988	P04274 →
P50130	—	0.988	P50130 →
P42288	—	0.987	P42288 →
O42384	—	0.987	O42384 →
O42574	—	0.987	O42574 →
DRD1	D(1A) dopamine receptor	0.987	landscape →
Q28044	—	0.987	Q28044 →
Q95136	—	0.987	Q95136 →
A0A678XMK4	—	0.987	A0A678XMK4 →
P51046	—	0.986	P51046 →
Q16950	—	0.986	Q16950 →
Q61121	—	0.986	Q61121 →
P42290	—	0.986	P42290 →
Q28997	—	0.986	Q28997 →
Q16951	—	0.985	Q16951 →
Q62758	—	0.985	Q62758 →
Q5IS72	—	0.984	Q5IS72 →
P25102	—	0.984	P25102 →
Q15760	—	0.984	Q15760 →