Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.45 |
| ▸ | KIT | P10721 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | KIF5B | P33176 | 2/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26103564 | 0.84 | KIT (0.51) | EGFRKITKDRAURKAPDGFRB | |
| SCHEMBL30395126 | 0.84 | KIT (0.51) | EGFRKITKDRAURKAPDGFRB | |
| SCHEMBL26101805 | 0.83 | KIT (0.46) | EGFRKITKDRRETKIF5B | |
| SCHEMBL30891778 | 0.81 | MAPK7 (0.45) | EGFRKITKDRPDGFRBPDGFRA | |
| SCHEMBL26099862 | 0.81 | MAPK7 (0.45) | EGFRKITKDRPDGFRBPDGFRA | |
| SCHEMBL26101118 | 0.80 | KIT (0.43) | EGFRKITKDRPDGFRBPDGFRA | |
| SCHEMBL26103035 | 0.79 | KIT (0.46) | EGFRKITKDRPDGFRBPDGFRA | |
| SCHEMBL30394404 | 0.79 | AURKA (0.47) | EGFRKITKDRAURKAPDGFRB | |
| SCHEMBL29238240 | 0.79 | MAPK7 (0.41) | EGFRKITKDRAURKAPDGFRB | |
| SCHEMBL26535219 | 0.79 | KIT (0.50) | EGFRKITKDRAURKAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023075529-A1 | QUINAZOLINE DERIVATIVE COMPOUND AND USE THEREOF | 보로노이바이오 주식회사 | 2023-05-04 | — | — | WO | disclosed |