Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.43 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.43 |
| ▸ | USP8 | P40818 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26103306 | 0.79 | CYP1A1 (0.47) | CYP1A1CYP1B1USP8CCNT1CDK9 | |
| SCHEMBL26101770 | 0.76 | CYP1A1 (0.44) | CYP1A1CYP1B1USP8JAK2CCNT1 | |
| SCHEMBL16564212 | 0.76 | ALDH1A1 (0.49) | CYP1A1CYP1B1JAK2TNKSPARP1 | |
| SCHEMBL26103326 | 0.76 | PIM1 (0.49) | TNKSPARP1TNKS2CHEK1 | |
| SCHEMBL20492643 | 0.76 | PARP1 (0.49) | IP6K1IP6K3TNKSPARP1TNKS2 | |
| SCHEMBL1789896 | 0.76 | HPGD (0.49) | CYP1B1IP6K1IP6K3TNKSPARP1 | |
| SCHEMBL4876138 | 0.74 | PIK3CD (0.71) | PIK3CDPIK3CAPIK3CBIP6K1IP6K3 | |
| SCHEMBL20971051 | 0.71 | PIK3CD (0.44) | PIK3CDPIK3CAPIK3CBIP6K1IP6K3 | |
| SCHEMBL4869700 | 0.71 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBIP6K1IP6K3 | |
| SCHEMBL25138197 | 0.69 | KMT2A (0.55) | CYP1A1CYP1B1USP8ASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076849-A1 | INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023076849-A1 | INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |