Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30490644 | 0.79 | UHRF1 (0.52) | UHRF1DYRK1ACCR1CCR5CCR8 | |
| SCHEMBL84469 | 0.79 | UHRF1 (0.52) | UHRF1DYRK1ACCR1CCR5CCR8 | |
| SCHEMBL4061188 | 0.78 | UHRF1 (0.42) | UHRF1DYRK1ASMARCA2SMARCA4PSEN1 | |
| SCHEMBL2610400 | 0.77 | UHRF1 (0.50) | UHRF1DYRK1ACCR1CCR5CCR8 | |
| SCHEMBL11075725 | 0.77 | UHRF1 (0.50) | UHRF1DYRK1ACCR1CCR5CCR8 | |
| Bromide SCHEMBL14676184 | 0.77 | UHRF1 (0.41) | UHRF1DYRK1ASMARCA2SMARCA4PSEN1 | |
| SCHEMBL4327140 | 0.76 | UHRF1 (0.48) | UHRF1DYRK1ACCR1CCR5CCR8 | |
| SCHEMBL21762132 | 0.76 | UHRF1 (0.48) | UHRF1DYRK1ACCR1CCR5CCR8 | |
| SCHEMBL20508491 | 0.76 | UHRF1 (0.48) | UHRF1DYRK1ACCR1CCR5CCR8 | |
| SCHEMBL17000190 | 0.76 | UHRF1 (0.48) | UHRF1DYRK1ACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268848-B2 | Cyclopropane compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-09-18 | — | — | US | disclosed |
| US-20120095031-A1 | CYCLOPROPANE COMPOUND | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095031-A1 | CYCLOPROPANE COMPOUND | HCRTR1, HCRTR2, CNR1 | UHRF1 3348/4885DYRK1A 788/4885CCR1 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.