Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.30 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30041499 | 1.00 | CSNK1A1 (0.45) | CSNK1A1CLK4PIN1PRKCQKMT2A | |
| SCHEMBL30801506 | 0.79 | KDM4E (0.38) | PRKCQKMT2AMAPK8MAPK9AURKA | |
| SCHEMBL13736418 | 0.79 | KDM4E (0.38) | PRKCQKMT2AMAPK8MAPK9AURKA | |
| SCHEMBL26100830 | 0.78 | CSNK1A1 (0.41) | CSNK1A1CLK4PIN1KMT2AALDH1A1 | |
| SCHEMBL29943928 | 0.78 | CSNK1A1 (0.41) | CSNK1A1CLK4PIN1KMT2AALDH1A1 | |
| SCHEMBL12985293 | 0.77 | GSK3A (0.41) | KMT2AMAPK8MAPK9GABBR2GABBR1 | |
| SCHEMBL29943664 | 0.77 | CSNK1A1 (0.40) | CSNK1A1CLK4PIN1ALDH1A1L3MBTL1 | |
| SCHEMBL26103054 | 0.77 | CSNK1A1 (0.40) | CSNK1A1CLK4PIN1ALDH1A1L3MBTL1 | |
| SCHEMBL24267966 | 0.76 | MAPK8 (0.32) | MAPK8 | |
| SCHEMBL30041073 | 0.76 | CYP1A2 (0.33) | PRKCQKMT2AMAPK8MAPK9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230137932-A1 | CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230137932-A1 | CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230137932-A1 | CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-05-04 | — | — | US | disclosed |
| EP-4087571-A1 | CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2 | Dana-Farber Cancer Institute, Inc. (US) | 2022-11-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230137932-A1 | CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2 | ERBB2, EGFR, ERBB3 | CSNK1A1 139/4885CLK4 643/4885PIN1 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.